**Links to**: [[Desire]], [[Psychoanalysis]], [[Psychosis]], [[07 Phenomenology of Sick Spirit]], [[Illness]], [[Falling ill]], [[10 Bias, or Falling into Place]]. Depression is the _undesiring_ and the _undesirable_ condition. %% A recent insight I gained from depression being suddenly forced upon me by lack of mineralocorticoid receptor stimulation is that, because one feels so bad, that state is neither coherent with imagined past trajectories that led to it (so everything feels like it has been a lie, because the result is this, and the present self is not compatible with imagined past selves), nor, especially, is it obvious to find solutions for survival, because surviving in that state would imply continuing to suffer. When one feels good, one obviously wants to continue to actualize that self. (put this in phenom) ___ Carhart-Harris & Friston 2019, REBUS: “ The process of capture ([Kessler, 2016](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588209/#B144)) or tightening of beliefs (and behaviors) in uncertainty ([Carhart-Harris, 2019](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588209/#B42)) may begin with psychological injury ([Hovens et al., 2015](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588209/#B127); [Peters et al., 2017](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588209/#B203))[8](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588209/#FN12) and then develop progressively, likely as an (functional) attempt to mitigate the averseness of felt uncertainty or ambiguity brought on by the relevant shock(s) and/or psychological injury or injuries. In this sense, the creation of the aberrant belief is self-protective and defensive (i.e., it is a coping mechanism), and, although pathologic, it may work to reduce an individual’s felt uncertainty. Indeed, as a strategy for suppressing uncertainty, even aberrant belief formation is consistent with the uncertainty-resolving imperatives of the free-energy principle. However, because the relevant defensive belief(s) becomes defining of pathology, it follows that it must be revised to avoid becoming entrenched and thus resistant to treatment. Moreover, because the belief(s) is self-protective, it is natural that psychological resistance will be felt if its integrity is threatened, e.g., pharmacologically via a psychedelic, or in the context of psychodynamic psychotherapy. It also follows that the precision weighting of the relevant high-level prior(s) or beliefs must first be relaxed, before they can be revised, and that a safe container for such a potentially destabilizing process is essential ([Carhart-Harris et al., 2018c](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588209/#B57)).” on anxiety: https://www.medrxiv.org/content/10.1101/2024.02.18.24302985v1 Disagree with Dewey here: "![[Pasted image 20221027025414.png|300]]" we may absolutely be indifferent in depression _________ Disagree with Jason Smith preface/Bifo Berardi: ![[Pasted image 20230118221847.png]] ________ See this: https://psyche.co/ideas/depression-is-more-than-low-mood-its-a-change-of-consciousness